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About
We are a multidisciplinary research & education group focused on epidemiology. This is the discipline that investigates the dissemination and determinants of disease and health in human populations. Epidemiology is indispensable in applied clinical and public health research.
Contact
Scope and scope of work
We seek to improve lifestyle, well-being and health of the (Dutch) population, specifically with respect to cancer-related and perinatal outcomes.
Read moreScope and scope of work
The mission of the Epidemiology R&D group is to improve lifestyle, well-being and health of the (Dutch) population, specifically with respect to cancer-related and perinatal outcomes, through high-quality and innovative epidemiological research and education.
Our research focuses on developing and improving strategies in etiology, prevention, early detection, prognosis, prediction and (quality of) care. We apply both observational and interventional methods. We work multidisciplinary where possible, increasing the chances of (clinical) embedding of the results after a research project.
Our ambition is to teach students, PhD students and other clinical and biomedical researchers state-of-the-art methods of applied medical scientific research and epidemiology. Through education and consultation, we enable students and researchers to conduct and evaluate applied scientific research in a sound manner. In doing so, we contribute to improving the scientific quality of research at Radboudumc and beyond.
Chairs/RGL's
- Cancer epidemiology - Bart Kiemeney
- View Radboudumc profile page and view research group
- Genetic epidemiology - Sita Vermeulen
- View Radboudumc profile page and view research group (link will follow)
- Personalized cancer screening - Mireille Broeders
- View Radboudumc profile page
Projects
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For etiological and prognostic research, we collect DNA and clinical information from children with congenital disorders and their parents. Mothers also complete a questionnaire about conditions during pregnancy.
More information on the projectwebsite.
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The ARM-Net Consortium is a group of professionals and patient representatives. The aim is to share data and knowledge for the purpose of research on congenital anorectal malformations and improvement of clinical care.
More information can be found at the projectwebsite.
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Using information and material from the AGORA databank and biobank, we are conducting research in a consortium with 4 other UMCs on the aetiology and prognosis of congenital kidney and urinary tract disorders.
More information can be found on the projectwebsite.
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Using information and material from the NBCS and UroLife biobank, among others, we investigate the genetic and molecular factors influencing the response to BCG immunotherapy in bladder cancer.
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In this project we aim to optimize follow-up for prostate cancer patients according to their individual risk of biochemical recurrence, late adverse effects of treatment and health-related quality of life.
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In collaboration with Aarhus University, we are developing a mixed model for application in genome-wide association studies (GWAS). This will be implemented in the LDAK software.
More information can be found on the projectwebsite.
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Within this project, we are looking for rare, inherited DNA variants that cause familial bladder cancer and bladder cancer at a very young age.
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Within the GWAS consortium for non-muscle-invasive bladder cancer, we use Mendelian Randomisation (MR) analyses to understand the relationship between body composition and outcomes in non-muscle-invasive bladder cancer.
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In this European project, we are analysing clinical and -omics data from many biobanks and conducting lab experiments to better understand relevant tumour-host interactions in melanoma, bladder and lung cancer.
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The NBS is a reference population for research on the role of genetic variation, lifestyle and environmental factors in health and disease. The NBS includes questionnaire data for ~9500 individuals and lab values for ~6500 individuals. In addition, there is genetic data from ~5500 individuals.
More information can be found at the projectwebsite.
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To investigate the role of lifestyle, clinical, and genetic and molecular factors in relation to bladder cancer risk and progression, this biobank with information and material from 2,500 bladder cancer patients was set up.
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In this multicenter randomized controlled trial, we investigate the additional beneficial value of FDG PET-CT in the follow-up of lung cancer patients.
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Personalized care in oncology: in this consortium, we develop the next generation of AI models for shared decision making in oncology.
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The aim of the PREFER study is to investigate whether we can make the population screening for cervical cancer more 'tailored' by including the risk of cervical cancer in which follow-up tests are carried out and how often they are done.
More information can be found at the projectwebsite.
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The PRIDE (PRegnancy and Infant DEvelopment) Study is a large survey of pregnant women in the Netherlands. These women and their children are followed for a longer period to discover factors that influence the health of mother and child.
More information can be found at the projectwebsite.
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In this study, we collected data on risk factors for breast cancer. By modelling, we look at the effect of offering the high-risk group a more extensive and the low-risk group a less extensive population screening.
More information can be found at the projectwebsite.
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In this project we identified a subset of the Patient Reported Outcomes version of the Common Terminology Criteria for Adverse Events (PRO-CTCAE) for standardized symptom monitoring in rectal cancer.
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ReLife is a multicentre prospective cohort study of 368 people with localised kidney cancer on the relationship lifestyle, clinical outcomes and quality of life.
More information can be found at the projectwebsite.
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This cohort study in the Dutch population-based breast cancer screening aims to determine the short- to long-term effect of tomosynthesis, replacing digital mammography, in population-based breast cancer screening.
More information can be found at the projectwebsite.
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In this project, we develop a risk-stratified follow-up care model for lung cancer patients.
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UroLife is a multicentre prospective cohort study of over 1,500 people with non-muscle-invasive bladder cancer on the relationship lifestyle, clinical outcomes and quality of life.
More information can be found at the projectwebsite.
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In this project, we develop a group-based multitrajectory model to identify clusters of patients with distinct symptom development over time.
Post-initial education
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This course focusses on the design of scientific research. Topics include choosing appropriate designs for a research question, advanced designs for randomized, non-randomized trials and observational studies, selecting study population and applying sampling methods, different types of biases and models for causality.
More information can be found here.
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Three-day course developed for PhD students in the Department of Genetics (and SD Medical BioSciences), focusing on basic statistical concepts and analyses, working in Linux, and when and how to seek help for epidemiological and statistical questions.
Consultancy/services
If you are interested in consultations or services from a R&E group, please fill in our application form: aanvraagformulier
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Radboudumc researchers can consult epidemiologists on research design and conduct, study designs, data collection, data management, analysis, and interpretation and implementation.
Registration Epidemiologist A and B
National registration as Epidemiologist A or B is possible for scientifically trained and practice-trained epidemiologists who are able to function in epidemiological research and education, in counselling or in policy preparation concerning (public) health problems. Discuss training and registration opportunities with accredited Epidemiology trainer Dr Femmie de Vegt (e-mail).
See also:
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Femmie de Vegt Associate professor epidemiology and principal lecturer
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Sita Vermeulen Associate Professor
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